Domino reaction of N-(cyanomethyl)-1,3-azolium quaternary salts with o-hydroxybenzaldehydes: scope and limitations

Domino reaction of N-(cyanomethyl)-1,3-azolium quaternary salts with o-hydroxybenzaldehydes: scope and limitations

A route towards chromenes, annulated with an imidazo[5,1-c][1,4] thiazine core through a base-promoted domino reaction of thiazolium quaternary salts, has been developed. The synthesised compounds show high cytotoxic activity against human tumour cell lines.

http://pubs.rsc.org/-/content/articlelanding/2015/ra/c4ra14122a#!divAbstract
http://repository.vnu.edu.vn/handle/VNU_123/33081